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The brain functions through interactions between neurochemicals such as GABA (the inhibitory neurotransmitter) and glutamate (the excitatory neurotransmitter) that produce electrical activity. Epilepsy is characterized by recurrent episodes of abnormal activity in the brain resulting in sudden, excessive and disorganized discharge of brain cells known as seizures.
While the exact way in which Zonegran works is unknown, it appears to work through a broad range of mechanisms such as blocking of sodium and calcium channels, enhancing GABA and blocking glutamate. These multiple mechanisms are thought to allow Zonegran to exert its antiseizure effects.
Zonegran is indicated as adjunctive therapy in the treatment of partial seizures in adults with epilepsy.
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